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The requirement for new prescriptions rather than refills primarily pertains to Schedule II drugs. These drugs, which include powerful opioids, stimulants, and certain sedatives, are subject to stringent regulations due to their high potential for abuse and dependence. The Drug Enforcement Administration (DEA) has established strict guidelines that mandate that these medications cannot be refilled and must be prescribed afresh each time a patient needs a new supply.

This regulation is designed to closely monitor the prescription and dispensing of these substances, ensuring that they are used safely and appropriately. In contrast, Schedule I drugs are not prescribed legally for medical use, while general prescription drugs and over-the-counter medications do not typically fall under such stringent scheduling laws and can usually be refilled as per the provider’s discretion. Therefore, the requirement for new prescriptions aligns specifically with the regulations governing Schedule II drugs.